X2, My truck is completly stock performance wise and I saw great gains with the Hypertech.omegafiler Just the opposite. When it comes to performance, the Hypertech is one of the least aggressive handheld tuners for your vehicle. They're specifically designed for stock to near-stock vehicles.
In fact, if you did have any extensive mods beyond the basics, such as cat-back exhaust/intake, that's when the handheld wouldn't be the best route and you'd really want to look into a custom tune.
Of course, you can go with a custom tune with a stock vehicle and still get much better performance than a handheld. But for mileage, I know at least one other user on here has tested the Hypertech and got a noticable increase in MPG.