No I don't think you could fit a 45 profile. Stock 2wd the biggest is gonna be probly 295/35. 24's will give you a much harsher ride then those 17's. I moved up to 20's with a little more aggresive tire and noticed very little. Awhile back, Truckin Mag did a special on I think 22's and 24's and they said it was a night a day difference on quality and comfort. This was on I think an 07 escalade.