congrats on the new truck.
so as silveradotrailblazer said larger tires will act like the 3.42 or 3.55 gears which in theory will help highway mileage a little as long as its flat due to lower rpms. but larger tires add rolling resistance and in the city the truck will have to work harder to get moving. Also harder getting up and down hills on the highway. Unfortunately only so much you can do with that big of a truck with the 6.0. should get better mileage than my 6.0 though.